Children’s health is particularly sensitive to the environment. What they are exposed to during early years can have a significant impact on their healthy development. To better understand these health pathways and how to improve children’s health outcomes, the Canadian Institutes of Health Research funded three research projects considering different aspects of child health: obesity, IBD and asthma & COPD. In this webinar, learn what the researchers discovered through their project and what they plan to do next.
About the Projects
The Developmental Origins of Pediatric Obesity and Obesity-Related Complications
This translational project studies clinical populations of pregnant mothers, their children and parallel rodent model systems in order to determine how early life environmental exposures (e.g.- maternal diets, high blood sugars etc.) affect the genes of the children to influence their risk for obesity. We will also determine whether altering the early life environment (e.g.- through diet etc.) modifies disease risk factors in children most susceptible for obesity. The identification of new early life biomarkers of disease could prevent the extensive health and financial burden of obesity.
The diet-microbiota-gut axis in pediatric IBD
This research program investigates the complex interactions among diet, the gut microbiota, and the host. It provides information that may be essential for personalized dietary and microbiota changes required to keep people with inflammatory bowel disease (IBD) in remission. It is well accepted that the gut microbiota plays a crucial role in the digestion of food, particularly plant-derived starches, and the production metabolites essential for human health. The primary objective of the proposed research is to investigate the complex tripartite interactions between the diet, the gut microbiota, and the host. Additionally, this study aims to characterize the role of microbial food-derived metabolites in pediatric IBD. This study will generate the information necessary for developing methods to improve bacterial activities in our intestine as treatment for IBD patients. This research will have important implications for the quality of life of people with IBD everywhere.
Gene and environment effects on lung health and risk for chronic respiratory disease, asthma & COPD
This project studies a group of babies that have been followed since birth, whose families have filled out lots of questions about what they eat, breathe and how often they get sick. These kids and their families have also done breathing tests that measure how well their lungs are doing. From studying all of this information, we believe we can discover what things each person can do to improve their lungs and prevent them from getting chronic breathing problems, making Canada the healthiest place to live.
About the Presenters
The Developmental Origins of Pediatric Obesity and Obesity-Related Complications
Dr. Vern Dolinsky conducts research at the forefront of understanding the underlying mechanisms of gestational diabetes and its impact on the developmental origins of obesity, diabetes, and cardiovascular disorders in youth. His lab employs a cutting-edge combination of experimental animal models, in vivo imaging, and cellular, molecular, biochemical, and “-omic” technologies to uncover new insights into the biological processes that lead to these conditions. These findings have the potential to revolutionize the development of therapies for the treatment of obesity, diabetes, and heart disease. His work is not only advancing our understanding of these conditions, but also pushing the boundaries of what is possible in biomedical research.
The diet-microbiota-gut axis in pediatric IBD
Alain Stintzi, Ph.D. is a professor with the Department of Biochemistry, Microbiology and Immunology, a member of the Ottawa Institute of Systems Biology, and Vice-Dean of Graduate and Postdoctoral Studies at the Faculty of Medicine, University of Ottawa. Dr. Stintzi obtained his Ph.D. in Molecular and Cellular Biology at the Louis-Pasteur University, France (1997). He was subsequently a Postdoctoral fellow at the Department of Chemistry, University of California at Berkeley. In 2000, he was appointed Assistant Professor at the Department of Veterinary Pathobiology, Oklahoma State University. Dr. Stintzi has considerable experience in systems biology approaches to study the role of the gut microbiota in infectious and chronic diseases. Dr. Stintzi has published over 130 articles and book chapters and has contributed to more than 150 scientific and educational conferences.
Gene and environment effects on lung health and risk for chronic respiratory disease, asthma & COPD
Dr. Padmaja Subbarao is a Clinician-Scientist in Paediatric Respiratory Medicine, specializing clinically in severe asthma. Trained in both Epidemiology and infant and preschool lung function, she holds appointments at the University of Toronto in the Departments of Paediatrics, Physiology and in the Dalla Lana School of Public Health.
Dr. Subbarao’s research program focuses on disentangling preschool wheeze heterogeneity to precisely predict who will develop each type of asthma, monitor its progression and discover the risk factors, exposures and underlying biology associated with each asthma subtype. She is the Director of the CHILD cohort study, one of the largest, most intensively characterized asthma birth cohorts in the world. This world-leading study enabled the discovery of the importance of the gut microbiome for the protection against asthma (cited more than 500 times).
This webinar is presented in partnership with the National Collaborating Centre for Environmental Health.
